Multisystemic inflammatory syndrome in children with COVID-19: A rheumatology perspective / Síndrome inflamatorio multisistémico en niños con COVID-19: una visión desde la reumatología

ABSTRACT The coronavirus disease 2019 (COVID-19) produced by SARS-CoV-2 has taken on great importance in recent months, and is under constant investigation by different areas of medicine, including rheumatology, in search of the best scientific evidence. In the case of the pediatric population, it is particularly important as it was first thought that the impact of the pan-demic in this population would be less due to the low presence of severe cases. Evidence is now being reported of clinical pictures in children with a diagnosis of COVID-19 who are characterized by an altered inflammatory state consisting of a storm of pro-inflammatory cytokines that produces manifestations similar to those presented in autoimmune diseases, such as Kawasaki disease. It has been called Multisystemic Inflammatory Syndrome in children, temporarily associated with SARS-CoV-2 which, in many cases requires hospitalization in pediatric intensive care units and multidisciplinary management by various specialties.

RESUMEN La enfermedad por coronavirus 2019 (COVID-19), producida por el SARS-CoV-2, ha tomado una gran importancia en los últimos meses y se encuentra bajo constante investigación por distintas áreas de la medicina, incluida la reumatología, en la búsqueda de la mejor evidencia científica. En el caso de la población pediátrica cobra especial importancia puesto que en un principio se pensaba que el impacto de la pandemia en esta población sería menor, debido a la baja presencia de casos severos, pero la evidencia actual reporta la existencia de cuadros clínicos en niños con diagnóstico de COVID-19 que se caracterizan por un estado inflamatorio alterado consistente en una tormenta de citocinas proinflamatorias que produce manifestaciones similares a las presentadas en enfermedades autoinmunes como la enfermedad de Kawasaki. Se le ha denominado síndrome inflamatorio multisistémico en ninos asociado temporalmente con SARS-CoV-2, el cual en muchos casos precisa internación en unidades de cuidados intensivos pediátricos y el manejo multidisciplinario por diversas especialidades.

Lipoma arborescens de joelho em paciente com espondilite anquilosante: relato de caso e revisão da literatura / Lipoma arborescens of the knee in a patient with ankylosing spondylitis: case report and literature review

RESUMOLipoma arborescens (LA) é definido como uma proliferação vilosa lipomatosa da membrana sinovial com substituição difusa do tecido sinovial por células gordurosas maduras. A lesão é muito rara, envolve a articulação do joelho (região suprapatelar) e se associa a doenças articulares degenerativas. Descrevemos o caso de um paciente de sexo masculino, portador de espondilite anquilosante com quadro de monoartrite de joelho direito e aumento de volume importante na região suprapatelar. O diagnóstico de lipoma arborescens foi confirmado a partir da ressonância magnética do joelho direito.

ABSTRACTLipoma arborescens (LA) is defined as a villous lipomatous proliferation of the synovial membrane with diffuse substitution of the synovial tissue by mature fat cells. The injury is very rare, involving the knee joint (suprapatellar region) and is associated with degenerative joint disease. We describe the case of a male patient, suffering from ankylosing spondylitis with monoarthritis of the right knee and swelling in suprapatellar region important. The diagnosis of lipoma arborescens was confirmed from the MRI of the right knee.

Presentación de necrosis avascular de laextremidad esternal de la clavícula: enfermedadde Friedrich en la infancia / Presentation of avascular necrosis of the sternal end of the clavicle: Friedrich’s disease in childhood

Friedrich describió, en 1924, la necrosis avascular de la extremidad esternal de la claví-cula, de etiología incierta y poco frecuente. La afección, generalmente se manifiesta condolor en la articulación esternoclavicular y aumento de volumen de la extremidad esternalde la clavícula, que evoluciona con limitación para la movilidad del hombro. La mayoría delos pacientes presenta remisión de los síntomas con el tratamiento conservador, quedandola artroplastia de resección de la articulación esternoclavicular reservada para los casosdifíciles. Describimos el caso de una nina˜ de 2 anos ˜ y 3 meses de edad, con enfermedad deFriedrich, que recibió solo tratamiento conservador, presentando buena evolución...

[Lipoma arborescens of the knee in a patient with ankylosing spondylitis: case report and literature review]. / Lipoma arborescens de joelho em paciente com espondilite anquilosante: relato de caso e revisão da literatura.

Lipoma arborescens (LA) is defined as a villous lipomatous proliferation of the synovial membrane with diffuse substitution of the synovial tissue by mature fat cells. The injury is very rare, involving the knee joint (suprapatellar region) and is associated with degenerative joint disease. We describe the case of a male patient, suffering from ankylosing spondylitis with monoarthritis of the right knee and swelling in suprapatellar region important. The diagnosis of lipoma arborescens was confirmed from the MRI of the right knee.

Sinovitis villonodular pigmentada focal como diagnóstico diferencial de monoartritis de rodilla / Focal pigmented villonodular sinovitis in the differential diagnosis of knee monoarthritis

La sinovitis villonodular pigmentada (SVNP) es una proliferación sinovial benigna, asociada a depósitos de hemosiderina, que se origina en las articulaciones, bursas o vainas tendinosas. La articulación más afectada es la rodilla (80% de los casos) y menos frecuente hombro, codos y tobillos. La resonancia magnética, permite la detección de la SVNP y el estudio histopatológico hace la confirmación del diagnóstico. Describimos el caso de una paciente con monoartritis de rodilla izquierda que, después de múltiples estudios, la biopsia fue compatible con sinovitis villonodular pigmentada

Pigmented villonodular synovitis (PVNS) is a benign synovial proliferation associated with hemosiderin deposits, which originates in joints, bursa or tendon sheaths. The knee is the joint most commonly affected (80% of cases), and less frequently it can affect the shoulder, ankle and elbow. Magnetic Resonance Imaging (MRI) is used to detect PVNS, and histological analysis is used to confirm the diagnosis. We describe the case of a patient with monoarthritis of the left knee, who after multiple biopsy studies, it was found to be compatible with PVNS.

[Malignant peritoneal mesothelioma in patients without occupational exposure. Case report]. / Mesotelioma peritoneal maligno en paciente sin exposición ocupacional. Reporte de un caso.

Peritoneal mesothelioma is a rare malignancy that affects more women than men, with an average of 53 years old. The most important risk factor for developing the disease is chronic exposure to asbestos, becoming a disease of occupational origin. This type of cancer is difficult to diagnose, even for pathologists, with few cases reported in the literature as the most common presentation is the pleural type. We report the case of a male patient, without asbestos exposure, who presented malignantperitoneal mesothelioma.